Agarwal, P; Searls, DB. 2009. Can literature analysis identify innovation drivers in drug discovery?. NATURE REVIEWS DRUG DISCOVERY 8 (11): 865-878

[Eugene Garfield]

Agarwal, P; Searls, DB. 2009. Can literature analysis identify innovation drivers 
in drug discovery?. NATURE REVIEWS DRUG DISCOVERY 8 (11): 865-878.

Author Full Name(s): Agarwal, Pankaj; Searls, David B.

Language: English
Document Type: Article

Abstract: Drug discovery must be guided not only by medical need and 
commercial potential, but also by the areas in which new science is creating 
therapeutic opportunities, such as target identification and the understanding 
of disease mechanisms. To systematically identify such areas of high scientific 
activity, we use bibliometrics and related data-mining methods to analyse over 
half a terabyte of data, including PubMed abstracts, literature citation data and 
patent filings. These analyses reveal trends in scientific activity related to 
disease studied at varying levels, down to individual genes and pathways, and 
provide methods to monitor areas in which scientific advances are likely to 
create new therapeutic opportunities.

Addresses: [Agarwal, Pankaj; Searls, David B.] GlaxoSmithKline Inc, Computat 
Biol Dept, King Of Prussia, PA 19406 USA
Reprint Address: Agarwal, P, GlaxoSmithKline Inc, Computat Biol Dept, 709 
Swedeland Rd,POB 1539, King Of Prussia, PA 19406 USA.

E-mail Address: Pankaj.Agarwal at gsk.com
ISSN: 1474-1776
DOI: 10.1038/nrd2973
URL: http://www.nature.com/nrd/journal/v8/n11/full/nrd2973.html