Agarwal, P; Searls, DB. 2009. Can literature analysis identify innovation drivers in drug discovery?. NATURE REVIEWS DRUG DISCOVERY 8 (11): 865-878
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Agarwal, P; Searls, DB. 2009. Can literature analysis identify innovation drivers
in drug discovery?. NATURE REVIEWS DRUG DISCOVERY 8 (11): 865-878.
Author Full Name(s): Agarwal, Pankaj; Searls, David B.
Document Type: Article
Abstract: Drug discovery must be guided not only by medical need and
commercial potential, but also by the areas in which new science is creating
therapeutic opportunities, such as target identification and the understanding
of disease mechanisms. To systematically identify such areas of high scientific
activity, we use bibliometrics and related data-mining methods to analyse over
half a terabyte of data, including PubMed abstracts, literature citation data and
patent filings. These analyses reveal trends in scientific activity related to
disease studied at varying levels, down to individual genes and pathways, and
provide methods to monitor areas in which scientific advances are likely to
create new therapeutic opportunities.
Addresses: [Agarwal, Pankaj; Searls, David B.] GlaxoSmithKline Inc, Computat
Biol Dept, King Of Prussia, PA 19406 USA
Reprint Address: Agarwal, P, GlaxoSmithKline Inc, Computat Biol Dept, 709
Swedeland Rd,POB 1539, King Of Prussia, PA 19406 USA.
E-mail Address: Pankaj.Agarwal at gsk.com
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