Senn, S; Lee, S "The analysis of the AB/BA cross-over trial in the medical literature" PHARMACEUTICAL STATISTICS, 3 (2): 123-131 APR-JUN 2004

[Eugene Garfield]

Stephen Senn : E-mail Address: stephen at stats.gla.ac.uk


Author(s): Senn, S; Lee, S

Title    : The analysis of the AB/BA cross-over trial in the medical literature

Source   : PHARMACEUTICAL STATISTICS, 3 (2): 123-131 APR-JUN 2004

Language: English      Document Type: Article

Abstract:
The evolution of opinion as to how to analyse the AB/BA cross-over trials is
described by examining the recommendations of three key papers. The impact
of these papers on the medical literature is analysed by looking at citation
rates as a function of various factors. It is concluded that amongst
practitioners there is a highly impel fect appreciation of the issues raised
by the possibility of carry-over. Copyright (C) 2004 John Wiley Sons Ltd.

EXCERPT FROM PAPER :

PURPOSE OF THIS PAPER:

PURPOSE OF THIS PAPER:
The AB/BA cross-over trial has a poor reputation and a controversial
history, which we cover below.  That is not, however, the main purpose of
this paper.  The evolution of the analysis of cross-over trials in practice
has not necessarily  followed that of recommendations in the statistical
literature.  This evolution is currently being investigated by one of us
(SL) in a number of ways: first, changing recommendations in textbooks of
medical statistics; second, current practice in analysis within the
pharmaceutical industry third, the actual analysis of cross-over trials in
papers in the medical press, and finally, citation of key statistical papers
in the medical literature.  It is the last of these that forms the subject
of this paper.  We consider the pattern of citations over time for the three
key papers: Grizzle [4-6], Hills and Armitage [7] and Freeman [8].

However, because this is the first of the series of proposed papers
investigating the way in which cross-over trial are analysed in practice, we
devote considerable space to covering the history of the controversy.  This
will be done in the sections that follow before proceeding to the citation
analysis itself.



Addresses: Univ Coll London, Dept Epidemiol & Publ Hlth, London, England;
Univ Coll London, Dept Stat Sci, London, England

Reprint Address: Senn, S, Univ Coll London, Dept Epidemiol & Publ Hlth,
London, England.


Cited References:
BALAAM LN, 1968, BIOMETRICS, V24, P61.
COTTON JD, 1998, ANAL WITHIN SUBJECT.
FREEMAN PR, 1989, STAT MED, V8, P1421.
GARFIELD E, 1971, CURR CONTENTS, P224.
GARFIELD E, 1992, SCI PUBL POLICY, V19, P321.
GRIEVE AP, 1982, BIOMETRICS, V38, P517.
GRIZZLE JE, 1965, BIOMETRICS, V21, P467.
GRIZZLE JE, 1974, BIOMETRICS, V30, P727.
HILLS M, 1979, BRIT J CLIN PHARMACO, V8, P7.
JONES B, 2003, DESIGN ANAL CROSS OV.
LARSON HJ, 1963, BIOMETRIKA, V50, P391.
MCCULLAGH P, 1989, GENERALIZED LINEAR M.
NELDER JA, 1972, J ROYAL STAT SOC A, V132, P107.
PRICE DJD, 1965, SCIENCE, V149, P510.
RATKOWSKY DA, 1993, CROSS OVER EXPT DESI.
REDMAN J, 2001, J APPL CRYSTALLOGR 3, V34, P375.
SENN S, 1994, STAT METHODS MED RES, V3, P303.
SENN S, 1998, ENCY BIOSTATISTICS, V2, P1033.
SENN SJ, 1991, BRIT J CLIN PHARMACO, V32, P133.
SENN SJ, 2000, ENCY BIOPHARMACEUTIC, P142.
SENN SJ, 2002, CROSS OVER TRIALS CL.

Cited Reference Count: 21
Times Cited: 0

Publisher: JOHN WILEY & SONS INC
Publisher Address: 111 RIVER ST, HOBOKEN, NJ 07030 USA
ISSN: 1539-1604