[Sigmetrics] 'Supply', 'Demand', and 'Technological Capabilities' in terms of Medical Subject Headings; preprint

[Loet Leydesdorff]

The Interaction of  <http://arxiv.org/abs/1512.07250> 'Supply', 'Demand',
and 'Technological Capabilities' in terms of Medical Subject Headings: 

A Triple Helix Model of Medical Innovation <http://arxiv.org/abs/1512.07250>


 

Alexander M. Petersen, Daniele Rotolo, and Loet Leydesdorff

 

We develop a model of innovation that enables us to trace the interplay
among three key dimensions of the innovation process: (i) demand of and (ii)
supply for innovation, and (iii) technological capabilities available to
generate innovation in the forms of products, processes, and services.
Building on Triple Helix research, we use entropy statistics to elaborate an
indicator of mutual information among these dimensions that can provide
indication of reduction of uncertainty. To do so, we focus on the medical
context, where uncertainty poses significant challenges to the governance of
innovation. The Medical Subject Headings (MeSH) of MEDLINE/PubMed provide us
with publication records classified within the categories "Diseases" (C),
"Drugs and Chemicals" (D), "Analytic, Diagnostic, and Therapeutic Techniques
and Equipment" (E) as knowledge representations of demand, supply, and
technological capabilities, respectively. Three case-studies of medical
research areas are used as representative 'entry perspectives' of the
medical innovation process. These are: (i) Human Papilloma Virus, (ii) RNA
interference, and (iii) Magnetic Resonance Imaging. We find statistically
significant periods of synergy among demand, supply, and technological
capabilities (C-D-E) that points to three-dimensional interactions as a
fundamental perspective for the understanding and governance of the
uncertainty associated with medical innovation. Among the pairwise
configurations in these contexts, the demand-technological capabilities
(C-E) provided the strongest link, followed by the supply-demand (D-C) and
the supply-technological capabilities (D-E) channels. 

 

.        Research Policy (in press); doi:10.1016/j.respol.2015.12.004
<http://doi.org/10.1016/j.respol.2015.12.004> 

.        Preprint available at http://arxiv.org/abs/1512.07250 

.        apologies for cross-postings

 

  _____  

Loet Leydesdorff 

Professor, University of Amsterdam
Amsterdam School of Communication Research (ASCoR)

 <mailto:loet at leydesdorff.net> loet at leydesdorff.net ;
<http://www.leydesdorff.net/> http://www.leydesdorff.net/ 
Honorary Professor,  <http://www.sussex.ac.uk/spru/> SPRU, University of
Sussex; 

Guest Professor  <http://www.zju.edu.cn/english/> Zhejiang Univ., Hangzhou;
Visiting Professor,  <http://www.istic.ac.cn/Eng/brief_en.html> ISTIC,
Beijing;

Visiting Professor,  <http://www.bbk.ac.uk/> Birkbeck, University of London;


 <http://scholar.google.com/citations?user=ych9gNYAAAAJ&hl=en>
http://scholar.google.com/citations?user=ych9gNYAAAAJ&hl=en

 

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