Bolt, HM; Hengstler, JG Most cited articles in the Archives of Toxicology: the debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo studies ARCHIVES OF TOXICOLOGY, 82 (12): 881-883 DEC 2008

[Eugene Garfield]

E-mail Address: hengstler at ifado.de

Author(s): Bolt, HM (Bolt, H. M.); Hengstler, JG (Hengstler, J. G.) 

Title: Most cited articles in the Archives of Toxicology: the debate about 
possibilities and limitations of in vitro toxicity tests and replacement 
of in vivo studies 

Source: ARCHIVES OF TOXICOLOGY, 82 (12): 881-883 DEC 2008 

Language: English 

Document Type: Editorial Material 

Keywords Plus: PRIMARY HEPATOCYTES; OXIDATIVE STRESS; ENZYME-INDUCTION; 
DRUG-METABOLISM; BLOOD LEAD; CELLS; HEPATOTOXICITY; CYTOTOXICITY; 
TRANSPORTERS; APOPTOSIS 

Addresses: [Bolt, H. M.; Hengstler, J. G.] Univ Dortmund, Leibniz Res Ctr 
Working Environm & Human Factors, Inst Arbeitsphysiol, D-44139 Dortmund, 
Germany 

Reprint Address: Hengstler, JG, Univ Dortmund, Leibniz Res Ctr Working 
Environm & Human Factors, Inst Arbeitsphysiol, Ardeystr 67, D-44139 
Dortmund, Germany. 

E-mail Address: hengstler at ifado.de 

Cited Reference Count: 26 

Times Cited: 0 

Publisher: SPRINGER 

Publisher Address: 233 SPRING ST, NEW YORK, NY 10013 USA 

ISSN: 0340-5761 

DOI: 10.1007/s00204-008-0379-6 

29-char Source Abbrev.: ARCH TOXICOL 

ISO Source Abbrev.: Arch. Toxicol. 

Source Item Page Count: 3 

Subject Category: Toxicology 

ISI Document Delivery No.: 374QT 

BARBOSA F
Evaluation of the use of salivary lead levels as a surrogate of blood lead 
or plasma lead levels in lead exposed subjects 
ARCHIVES OF TOXICOLOGY 80 : 633 DOI 10.1007/s00204-006-0096-y 2006 

BARBOSA F
Clinical evidence for lead-induced inhibition of nitric oxide formation 
ARCHIVES OF TOXICOLOGY 80 : 811 DOI 10.1007/s00204-006-0111-3 2006 

BOETTCHER MI
Excretion of mercapturic acids of acrylamide and glycidamide in human 
urine after single oral administration of deuterium-labelled acrylamide 
ARCHIVES OF TOXICOLOGY 80 : 55 DOI 10.1007/s00204-005-0011-y 2006 

BRULPORT M
Fate of extrahepatic human stem and precursor cells after transplantation 
into mouse livers 
HEPATOLOGY 46 : 861 DOI 10.1002/hep.21745 2007 

CARMO H
Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis 
of phase I metabolism with hepatocytes of six species including human 
TOXICOLOGY 206 : 75 DOI 10.1016/j.tox.2004.07.004 2005 

GEBHARDT R
New hepatocyte in vitro systems for drug metabolism: Metabolic capacity 
and recommendations for application in basic research and drug 
development, standard operation procedures 
DRUG METABOLISM REVIEWS 35 : 145 DOI 10.1081/DMR-120023684 2003 

GREIM H
Toxicological comments to the discussion about REACH 
ARCHIVES OF TOXICOLOGY 80 : 121 DOI 10.1007/s00204-005-0039-z 2006 

HENGSTLER JG
Cryopreserved primary hepatocytes as a constantly available in vitro model 
for the evaluation of human and animal drug metabolism and enzyme 
induction 
DRUG METABOLISM REVIEWS 32 : 81 2000 

HEWITT NJ
Primary hepatocytes: Current understanding of the regulation of metabolic 
enzymes and transporter proteins, and pharmaceutical practice for the use 
of hepatocytes in metabolism, enzyme induction, transporter, clearance, 
and hepatotoxicity studies 
DRUG METABOLISM REVIEWS 39 : 159 DOI 10.1080/03602530601093489 2007 

HWANG JM
Berberine induces apoptosis through a mitochondria/caspases pathway in 
human hepatoma cells 
ARCHIVES OF TOXICOLOGY 80 : 62 DOI 10.1007/s00204-005-0014-8 2006 

KIM DW
Regulation of metal transporters by dietary iron, and the relationship 
between body iron levels and cadmium uptake 
ARCHIVES OF TOXICOLOGY 81 : 327 DOI 10.1007/s00204-006-0160-7 2007 

LI Y
Aristolochic acid I-induced DNA damage and cell cycle arrest in renal 
tubular epithelial cells in vitro 
ARCHIVES OF TOXICOLOGY 80 : 524 DOI 10.1007/s00204-006-0090-4 2006 

LILIENBLUM W
Alternative methods to safety studies in experimental animals: role in the 
risk assessment of chemicals under the new European Chemicals Legislation 
(REACH) 
ARCHIVES OF TOXICOLOGY 82 : 211 DOI 10.1007/s00204-008-0279-9 2008 

MBEMBAMEKA P
Role of oxidative stress and intracellular calcium in nickel carbonate 
hydroxide-induced sister-chromatid exchange, and alterations in 
replication index and mitotic index in cultured human peripheral blood 
lymphocytes 
ARCHIVES OF TOXICOLOGY 81 : 89 DOI 10.1007/s00204-006-0128-7 2007 

MONTENEGRO MF
A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies 
plasma/whole blood lead ratio 
ARCHIVES OF TOXICOLOGY 80 : 394 DOI 10.1007/s00204-005-0056-y 2006 

MOTO M
Possible involvement of oxidative stress in dicyclanil-induced 
hepatocarcinogenesis in mice 
ARCHIVES OF TOXICOLOGY 80 : 694 DOI 10.1007/s00204-006-0086-0 2006 

MYHRER T
Anticonvulsant effects of GABA(A) modulators microinfused into area 
tempestas or substantia nigra in rats exposed to soman 
ARCHIVES OF TOXICOLOGY 80 : 502 DOI 10.1007/s00204-006-0070-8 2006 

NAMPOOTHIRI LP
Effect of co-exposure to lead and cadmium on antioxidant status in rat 
ovarian granulose cells 
ARCHIVES OF TOXICOLOGY 81 : 145 DOI 10.1007/s00204-006-0133-x 2007 

OBRIEN PJ
High concordance of drug-induced human hepatotoxicity with in vitro 
cytotoxicity measured in a novel cell-based model using high content 
screening 
ARCHIVES OF TOXICOLOGY 80 : 580 DOI 10.1007/s00204-006-0091-3 2006 

RAULFHEIMSOTH M
Irritative effects of fumes and aerosols of bitumen on the airways: 
results of a cross-shift study 
ARCHIVES OF TOXICOLOGY 81 : 35 DOI 10.1007/s00204-006-0115-z 2007 

REISTAD T
Neurotoxicity of the pentabrominated diphenyl ether mixture, DE-71, and 
hexabromocyclododecane (HBCD) in rat cerebellar granule cells in vitro 
ARCHIVES OF TOXICOLOGY 80 : 785 DOI 10.1007/s00204-006-0099-8 2006 

SCHRICKX J
Ochratoxin A secretion by ATP-dependent membrane transporters in Caco-2 
cells 
ARCHIVES OF TOXICOLOGY 80 : 243 DOI 10.1007/s00204-005-0041-5 2006 

STEFANIDOU M
Zinc: a multipurpose trace element 
ARCHIVES OF TOXICOLOGY 80 : 1 DOI 10.1007/s00204-005-0009-5 2006 

WU CH
Immunohistochemical detection of apoptotic proteins, p53/Bax and JNK/FasL 
cascade, in the lung of rats exposed to cigarette smoke 
ARCHIVES OF TOXICOLOGY 80 : 328 DOI 10.1007/s00204-005-0050-4 2006 

YANG JH
Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human 
epidermal keratinocytes: evaluation based on in vitro cytotoxicity and 
interleukin-8 release 
ARCHIVES OF TOXICOLOGY 80 : 508 DOI 10.1007/s00204-006-0069-1 2006 

ZHAN XA
Evaluation of caspase-dependent apoptosis during fluoride-induced liver 
lesion in pigs 
ARCHIVES OF TOXICOLOGY 80 : 74 DOI 10.1007/s00204-005-0019-3 2006